Mac OS X:Build from source
A fully packaged binary application for Gramps on Mac is available (Intel only, yet) and is described at Using Gramps on Apple Mac.
There are at least three different ways of installing GRAMPS from source on Mac OS X. The linked pages provide step by step instructions.
The GTK-OSX version is the newest port, and least unlike a Mac native application. It is the one described at Using Gramps on Apple Mac. The build requires the Apple Xcode toolset, which is free. A single zip file provides the build environment, and one double-click in Finder does the build, ending up with a runnable packaged gramps application on the Desktop. Admin permission is not required. Sudo is not required. X11 is not required. The build takes about an hour on a modern iMac.
MacPorts X11 version
MacPorts is a packaging system for automatically downloading, compiling and installing Unix software on Mac OS X. It makes the process simple and almost entirely automatic.
See Mac OS X MacPorts on the installation process.
Fink X11 version
Similar to MacPorts, see Mac OS X:Build from source:fink.
An older attempt on PPC mac is described here
Are there any other options?
(1) Virtual Server
Another option is to install a virtual server on your Mac (like VMware Fusion), create a virtual machine running Linux, and install GRAMPS in there. A Gnome based distro like Ubuntu would be a good choice for the Linux system.
(2) Compile GRAMPS from source without a package manager
If you have all of the dependent libraries installed already, this should be possible. Just download the .tar.gz file, unpack it, and follow the INSTALL instructions.
If you have Bootcamp installed, you can use the Windows version of GRAMPS.
Is this going to be too complicated for me?
The GTK-OSX option can build Gramps from source on the Desktop without typing a single character! The X11 MacPorts option is very straight forward. The other options may be more complicated.