GRAMPS freezes and crashes
There have been multiple reports of long freezes and crashes of GRAMPS when refreshing the people view, e.g. after editing a person or changing the Name Display Format. They seem to be related to the use of GNOME Assistive Technologies. If you experience similar problems try going into System -> Preferences -> Assistive Technologies, unchecking "Enable assistive technologies" and logging out and in again.
GRAMPS runs out of locks
With a large database, GRAMPS can "run out of available locks". See bug report below.