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There have been multiple reports of long freezes and crashes of GRAMPS when refreshing the people view, e.g. after editing a person or changing the Name Display Format. They seem to be related to the use of GNOME Assistive Technologies. If you experience similar problems try going into System -> Preferences -> Assistive Technologies, unchecking "Enable assistive technologies" and logging out and in again.
* [http://bugzilla.gnome.org/show_bug.cgi?id=571596 GNOME Bug]
With a large database, GRAMPS can "run out of available locks". See bug report below.
* [http://www.gramps-project.org/bugs/view.php?id=2686 GRAMPS Bug and workarounds]